Iimveliso

Iimveliso ze-PO zineempembelelo ezintle kakhulu zokulwa ne-dandruff kunye ne-anti-itching, indlela ekhethekileyo yokulwa ne-dandruff, ukunyibilika okugqwesileyo kunye nokudibanisa, ukhuseleko, i-non-toxic, ayicaphuki, kwaye isetyenziswa kakhulu kwi-shampoo kunye neemveliso zokunakekelwa kweenwele.I-PO ineziphumo ezigqwesileyo zokulwa ne-antipruritic, kwaye inemisebenzi yokuvala inzala kunye ne-deodorization, ngoko ke isetyenziswe kwiindawo zokuhlambela ukufumana iziphumo ezilungileyo.I-PO inesiphumo esibanzi sokubulala kwi-fungi kunye nokungunda, kwaye inesiphumo esilungileyo sonyango kunyawo kunye ne-handworm.Ingasetyenziselwa ukugcinwa kwezinto zokuthambisa, njenge-bactericide kwisepha, kunye ne-agent agent.Ke ngoko, i-PO iyi-anti-dandruff esebenzayo kunye ne-antipruritic bactericide, esetyenziswa kakhulu kwishampu kunye neemveliso zokhathalelo lweenwele, izithambiso zokuhlambela, izithambiso, kunye nezicoci.

I-Piroctone olamine, ityuwa ye-ethanolamine ye-hydroxamic acid derivative Piroctone, i-agent ye-hydroxypyridone ye-anti-mycotic.I-Piroctone olamine ingena kwi-membrane yeseli kwaye yenza ii-complexes ezine-iron ion, inqanda imetabolism yamandla kwi-mitochondria [1].I-Piroctone olamine (PO) yityuwa ye-ethanolamine ye-hydroxamic acid derivative Piroctone.Zonke iintlobo ze-Candida zibonisa ubuncinci obuncinci bokugxininiswa kwe-inhibitory (MICs) ye-Piroctone olamine (0.125-0.5 μg / mL) kunye ne-Amphotericin B (AMB) (0.03-1 μg / mL).

Lo msebenzi ujolise ekuvavanyeni umsebenzi we-antifungal we-Piroctone olamine kunyango lwe-candidiasis yangaphakathi kwesisu kwimodeli yokulinga usebenzisa iigundane zaseSwitzerland.Unyango nge-Piroctone olamine (0.5 mg / kg) lwenziwa i-72 h emva kokusuleleka ngokuphathwa kwe-intraperitoneal.Ukuthelekisa, iqela lezilwanyana (n = 6) liphathwa nge-Amphotericin B (0.5 mg / kg).Ukuxilongwa kwe-mycological kwenziwa ngokuqokelela isibindi, i-spleen kunye nezintso.Idatha emalunga nokukhula kwefungal kunye nokufa zicazululwa ngokweenkcukacha-manani ngovavanyo loMfundi kunye nohlalutyo lokwahluka, kunye nenqanaba lokubaluleka elibekwe kwi-P.<0.05.Umahluko kumanqaku okukhula kokungunda phakathi kweqela lolawulo kunye namaqela onyango (i-Piroctone olamine kunye ne-Amphotericin B) ubalulekile ngokwezibalo (P<0.05)